Statins prevent the body from synthesizing cholesterol by blocking the HMG-CoA reductase enzyme—an enzyme also responsible for the synthesis of coenzyme Q10, also known as ubiquinone. Why do we care about this? CoQ10 is an essential component of our energy metabolism. Low levels of CoQ10 can lead to serious fatigue, poor heart function, and poor muscle metabolism. This is why everyone taking a statin needs to be on 100-200 mg of CoQ10 as well. A pilot study published in the December 5, 2012 issue of the Canadian Journal of physiology and Pharmacology found that giving patients who had statin-associated myopathy (muscle pain, stiffness, weakness) coenzyme Q10 decreased muscle pain, muscle cramps, and tiredness.
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