Medscape reports on a study presented at the American Academy of Neurology 65th Annual Meeting that found that 3 mg of fast-acting (not time-released) melatonin per day (taken between 10 and 11 pm) was more effective than placebo in treating migraines and was as effective as 25 mg of amitriptyline. Melatonin has fewer and less serious side effects, with lower rates of daytime sleepiness and no weight gain. Melatonin is a hormone produced by the pineal gland. In supplement form it is effective in attenuating jet lag and helping normalize sleep patterns. Subjects in the placebo and in the amitriptyline groups gained weight, while those in the melatonin group lost weight.
Other studies have found feverfew, butterbur, magnesium, and riboflavin to help reduce the frequency of migraines.
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